I have a been thinking about all the possible contributors to this condition which sadly affects so many people these days.
I don't think it is any one factor.
I I am guessing it is metal poisoning that happens because of the trans fats in margarines.
Both Aluminium production, and margarine began production around the same time. However I am sure early margarine wasn't hydrogenated. It was dyed, or sold with dye, and I wonder if the dye was toxic.
By the time aluminium cookware became widely used, margarine had morphed from being an animal fat product, to hydrogenated vegetable oils. I think these formed the sticky plaques that started to collect the particles of metals.
Post WW2 there was only margarine. Along with lots of canned foods, the now ubiquitous aluminium cookware and the metal scourers used such as Brillo pads.
The other interesting development was in the amount of nickel and alloys used in coinage, and that everyone handled coinage every day. Perhaps there was a lot of these metals in early childhood toys as well.
Then came the cans of fizzy drink, and beer in cans.
Amalgam fillings in teeth and metal in dentures. The ubiquitous tin foil that everything got cooked or wrapped in. Along with dishwashers and the chemicals used that break down aluminium and non stick cookware.
Certainly jewellery was worn with nickel and chromium plating. It was cheap and cheerful. Then I suppose these metals were used in cutlery.
Statistics indicate that it is two thirds women to a third men who are diagnosed with alzeimers. Women who wore jewellery did the shopping, worked as shop assistants perhaps handling coinage.
Alzeimers was first diagnosed around 1900. Time enough for these factors to start showing up.
One wonders what early chemists made their pills and potions from, I am sure they were using metal compounds.
Both of these sisters ate lots of biscuits and cake, all made with trans fats. Both cooked with aluminium pots and scoured them with Brillo pads. It was also quite normal to use washing soda in the washing up water to cut the grease.
Both ate margarine.
They both used tons of hairspray. I wonder if metal ions mixed in with the aerosols. The use of antiperspirant especially for men started in the 1960s.
I suppose lipstick would cover all of these toxins and fats as well. Lipstick started to become socially acceptable during the Second World War.
So many ways these metals have become a toxic burden to the environment. They are polluting all our water and land, and the air we breath.
Perhaps the reason third world poor countries do not have such a high incidence of these degenerative neural diseases, is that they do not have so many of these contact toxins, and didn't eat margarine.
They also didn't have access to Mercury amalgam fillings, or antiperspirant.
Nor modern medicines. Over use of Penicillin and Antibiotics has weakened our immune systems. We eat way too much sugar combined with fats and refined bleached flor. This causes sluggish digestion and elimination, so all the metals don't get flushed out of our system, they end up clogging up our brains.